解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90131-0
更新日期:1995-11-01 00:00:00
abstract::Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyroph...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90178-7
更新日期:1995-10-01 00:00:00
abstract::Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90120-5
更新日期:1995-09-01 00:00:00
abstract::Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90162-0
更新日期:1995-07-01 00:00:00
abstract::T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhanc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90161-2
更新日期:1995-07-01 00:00:00
abstract::Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90013-6
更新日期:1995-06-01 00:00:00
abstract::ZAP-70 and Syk are PTKs required for TCR and BCR function, respectively. Loss of the Syk PTK results in a nonfunctional BCR. We provide evidence here that ZAP-70 and Syk are functionally homologous in antigen receptor signaling by demonstrating that expression of ZAP-70 in Syk- B cells reconstitutes BCR function. Reco...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90029-2
更新日期:1995-05-01 00:00:00
abstract::Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90025-x
更新日期:1995-05-01 00:00:00
abstract::The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90146-9
更新日期:1995-04-01 00:00:00
abstract::Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90142-6
更新日期:1995-04-01 00:00:00
abstract::Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90048-9
更新日期:1995-03-01 00:00:00
abstract::Using a fluorescein-conjugated antigenic peptide, peptide-receptive H-2Kb MHC class I molecules were found throughout the secretory pathways of RMA cells and peptide transporter (TAP)-deficient derivative cells (RMA/S). RMA/S cells displayed higher levels of intracellular peptide-receptive molecules, while, surprising...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(95)80014-x
更新日期:1995-02-01 00:00:00
abstract::Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within m...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90076-4
更新日期:1995-01-01 00:00:00
abstract::B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(94)80021-9
更新日期:1994-12-01 00:00:00
abstract::Recent experiments involving disruption of the Oct-2 gene have shown that this largely B cell-restricted transcription factor is not required in the early stages of B cell development. However, B cells that lack Oct-2 may be blocked from differentiation past the surface immunoglobulin-positive stage. To identify a pos...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90034-5
更新日期:1994-11-01 00:00:00
abstract::B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90094-9
更新日期:1994-09-01 00:00:00
abstract::Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90070-1
更新日期:1994-08-01 00:00:00
abstract::Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were an...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90100-7
更新日期:1994-06-01 00:00:00
abstract::The identification is made in normal mice of the stages in T cell development at which the rearranged beta chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCR alpha chain. In addition, evidence is provided that utilization of beta chains in T cell progenitors does not pr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90102-3
更新日期:1994-05-01 00:00:00
abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90010-8
更新日期:1994-04-01 00:00:00